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A true penicillin allergy is caused by antibodies that the immune system has formed against the antibiotic When sinusitis is considered together with commonly associated comorbid conditions such as allergic rhinitis, asthma, and chronic bronchitis, exacerbation of these diseases affects more than 90 million people—nearly one in three Americans. 5 The socioeconomic impact of this translates to more than $5. Learn about the diseases and conditions that may cause leg sores, and read about the medications used in treatment. Learn about allergy medicine Find information about which conditions Bactrim DS Oral is commonly used to treat User Reviews for Bactrim DS. - Answered by a verified Pharmacist. The following information is NOT intended to endorse drugs or recommend therapy. Pinpoint your symptoms and signs with MedicineNet's Symptom Checker Allergies to sulfonamides, also known as sulfa drugs, are common. 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